Researchers conducted a study with two compounds- epigallocatechin-3-gallate and ferulic acid and found that these compounds contributed in reversing Alzheimer’s symptoms.
The compound epigallocatechin-3-gallate or EGCG is a key ingredient found in green tea, while ferulic acid FA is present in carrots, tomatoes, rice, wheat, and oats. The study shows that some dietary changes can help the body to fight Alzheimer’s symptoms. The detail work of the study was published in the Journal of Biological Chemistry in March 2019 edition.
The researchers analyzed a group of mice with Alzheimer’s symptom and placed the 32 mice into different groups. Each groups were provided with different dietary supplement. The groups contained both healthy and Alzheimer’s symptom mice in equal number.
The groups were provided with combination of EGCG and FA, or EGCG or FA only, or a placebo for three months. The mice were fed with a dosage of 30 milligrams (mg) per kilogram of body weight, which is a recommended dosage and well tolerated by humans.
The researchers made a list of the neurological tests of the mice before and after the test. The parameters listed included those tests linked to thinking and memory test that are mainly linked with dementia in humans.
The researchers assessed the mice spatial working memory by observing their activity in the Y-shaped maze. The healthy mice were able to access the three rows of the maze in sequence for food, most of the time. However, the Alzheimer’s symptom mice could not perform this activity.
After the test, the tam observed that the group under combinational treatment of both the compounds showed the best result in the Y-shaped maze test. All the mice, healthy and Alzheimer’s effected, were able to access the three row of maze successfully.
The compounds ECGA and FA were found to reduce neuroinflammation and oxidative stress in the brain, which proves that dementia and Alzheimer’s related disease might be curbed with its intake.